3WTX

Crystal structure of the complex comprised of ETS1(Y329A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, F)	Runt-related transcription factor 1	polymer	204	22913.8	2	UniProt (Q03347) Pfam (PF00853)	Mus musculus (mouse)	Acute myeloid leukemia 1 protein, Core-binding factor subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit
2	B, E (B, G)	Core-binding factor subunit beta	polymer	142	16684.7	2	UniProt (Q08024) Pfam (PF02312)	Mus musculus (mouse)	CBF-beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit
3	C, F (C, H)	Protein C-ets-1	polymer	166	19124.6	2	UniProt (P14921) Pfam (PF19525) Pfam (PF00178)	Homo sapiens (human)	p54
4	G, I (D, I)	DNA (5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3')	polymer	15	4513.9	2
5	H, J (E, J)	DNA (5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3')	polymer	15	4665.0	2
6	K, L, M, N, O... (A, B, C, F, G...)	water	water		18.0	21	Chemie (HOH)

Sequence modifications

A, F: 60 - 263 (UniProt: Q03347)

PDB	External Database	Details
Lys 94	Leu 94	engineered mutation

C, H: 276 - 441 (UniProt: P14921)

PDB	External Database	Details
Ala 329	Tyr 329	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	135804.3
All*	Total formula weight	135804.3

*Water molecules are not included.