3WTS
Crystal structure of the complex comprised of ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, F) | Runt-related transcription factor 1 | polymer | 205 | 23045.0 | 2 | UniProt (Q03347) Pfam (PF00853) | Mus musculus (mouse) | Acute myeloid leukemia 1 protein, Core-binding factor subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit |
| 2 | B, E (B, G) | Core-binding factor subunit beta | polymer | 142 | 16684.7 | 2 | UniProt (Q08024) Pfam (PF02312) | Mus musculus (mouse) | CBF-beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit |
| 3 | C, F (C, H) | Protein C-ets-1 | polymer | 166 | 19216.7 | 2 | UniProt (P14921) Pfam (PF19525) Pfam (PF00178) | Homo sapiens (human) | p54 |
| 4 | G, I (D, I) | 5'-D(*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3' | polymer | 15 | 4513.9 | 2 | |||
| 5 | H, J (E, J) | 5'-D(*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3' | polymer | 15 | 4665.0 | 2 | |||
| 6 | K, L, M, N, O... (A, B, C, F, G...) | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A, F: 60 - 263 (UniProt: Q03347)
| PDB | External Database | Details |
|---|---|---|
| Met 59 | - | expression tag |
| Lys 94 | Leu 94 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 136250.9 | |
| All* | Total formula weight | 136250.9 |
