3WQH
Crystal Structure of human DPP-IV in complex with Anagliptin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dipeptidyl peptidase 4 | polymer | 730 | 84616.8 | 2 | UniProt (P27487) Pfam (PF00930) Pfam (PF00326) | Homo sapiens (human) | ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV soluble form |
| 2 | C, D, E, F, G... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 13 | Chemie (NAG) | |||
| 3 | J, Q (A, B) | N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide | non-polymer | 383.4 | 2 | Chemie (SKK) | |||
| 4 | R, S (A, B) | water | water | 18.0 | 104 | Chemie (HOH) |
Sequence modifications
A, B: 39 - 766 (UniProt: P27487)
| PDB | External Database | Details |
|---|---|---|
| Gly 37 | - | expression tag |
| Pro 38 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 169233.6 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3642.6 | |
| All* | Total formula weight | 172876.2 |
