3WKC
Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bifunctional epoxide hydrolase 2 | polymer | 561 | 63514.5 | 1 | UniProt (P34913) Pfam (PF00702) Pfam (PF00561) | Homo sapiens (human) | Cytosolic epoxide hydrolase 2, CEH, Epoxide hydratase, Soluble epoxide hydrolase, SEH, Lipid-phosphate phosphatase |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | C (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | D (A) | 4-{2,5-dimethyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrrol-3-yl}-1,3-thiazol-2-amine | non-polymer | 277.4 | 1 | Chemie (S0J) | |||
| 5 | E (A) | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
A: 1 - 555 (UniProt: P34913)
| PDB | External Database | Details |
|---|---|---|
| His 556 | - | expression tag |
| His 557 | - | expression tag |
| His 558 | - | expression tag |
| His 559 | - | expression tag |
| His 560 | - | expression tag |
| His 561 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 63514.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 396.7 | |
| All* | Total formula weight | 63911.2 |
