3WJL
Crystal structure of IIb selective Fc variant, Fc(V12), in complex with FcgRIIb
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ig gamma-1 chain C region | polymer | 230 | 26009.3 | 2 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (human) | |
| 2 | C (C) | Low affinity immunoglobulin gamma Fc region receptor II-c | polymer | 179 | 20257.5 | 1 | UniProt (P31995) Pfam (PF13895) | Homo sapiens (human) | IgG Fc receptor II-c, CDw32, Fc-gamma RII-c, Fc-gamma-RIIc, FcRII-c |
| 3 | D (D) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1479.3 | 1 | In PDB GlyTouCan (G89993FE) | |||
| 4 | E (E) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 1 | In PDB GlyTouCan (G33244HE) | |||
| 5 | F (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | G, H, I (A, B, C) | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
A, B: 216 - 445 (UniProt: P01857)
C: 0 - 172 (UniProt: P31995)
| PDB | External Database | Details |
|---|---|---|
| Ser 220 | Cys 103 | engineered mutation |
| Asp 233 | Glu 116 | engineered mutation |
| Asp 237 | Gly 120 | engineered mutation |
| Asp 238 | Pro 121 | engineered mutation |
| Asp 268 | His 151 | engineered mutation |
| Gly 271 | Pro 154 | engineered mutation |
| Arg 330 | Ala 213 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| His 173 | - | expression tag |
| His 174 | - | expression tag |
| His 175 | - | expression tag |
| His 176 | - | expression tag |
| His 177 | - | expression tag |
| His 178 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 72276.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3104.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 75602.1 |
