3WJJ

Crystal structure of IIb selective Fc variant, Fc(P238D), in complex with FcgRIIb

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ig gamma-1 chain C region	polymer	230	25942.3	2	UniProt (P01857) Pfam (PF07654)	Homo sapiens (human)
2	C (C)	Low affinity immunoglobulin gamma Fc region receptor II-b	polymer	179	20257.5	1	UniProt (P31994) Pfam (PF13895)	Homo sapiens (human)	IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b
3	D, E (D, E)	beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1625.5	2	In PDB GlyTouCan (G33244HE)
4	F, G, H (A, B, C)	water	water		18.0	130	Chemie (HOH)

Sequence modifications

A, B: 216 - 445 (UniProt: P01857)

PDB	External Database	Details
Ser 220	Cys 103	engineered mutation
Asp 238	Pro 121	engineered mutation

C: 0 - 172 (UniProt: P31994)

PDB	External Database	Details
His 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag
His 178	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	72142.0
Branched	Number of molecules	2
	Total formula weight	3251.0
All*	Total formula weight	75393.0

*Water molecules are not included.