3WHA
Hsp90 alpha N-terminal domain in complex with a tricyclic inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Heat shock protein HSP 90-alpha | polymer | 229 | 25788.0 | 2 | UniProt (P07900) Pfam (PF13589) In PDB | Homo sapiens (human) | Heat shock 86 kDa, HSP 86, HSP86, Renal carcinoma antigen NY-REN-38 |
| 2 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | A, B | 4-{[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl]sulfanyl}butanamide | non-polymer | 415.9 | 2 | Chemie (WHA) | |||
| 4 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | water | water | 18.0 | 636 | Chemie (HOH) |
Sequence modifications
A, B: 9 - 236 (UniProt: P07900)
| PDB | External Database | Details |
|---|---|---|
| Met 8 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51575.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 948.2 | |
| All* | Total formula weight | 52524.1 |
