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3WF7

Crystal structure of S6K1 kinase domain in complex with a purine derivative 1-(9H-purin-6-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ARibosomal protein S6 kinase beta-1polymer32937178.81UniProt (P23443)
Pfam (PF00069)
Pfam (PF00433)
In PDB
Homo sapiens (human)S6K-beta-1, S6K1, 70 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase I, Serine/threonine-protein kinase 14A, p70 ribosomal S6 kinase alpha
2AZINC IONnon-polymer65.41Chemie (ZN)
3A1-(9H-purin-6-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamidenon-polymer390.41Chemie (FS9)
4AGLYCEROLnon-polymer92.11Chemie (GOL)
5waterwater18.0226Chemie (HOH)
Sequence modifications
A: 78 - 399 (UniProt: P23443)
PDBExternal DatabaseDetails
Gly 71-EXPRESSION TAG
Ser 72-EXPRESSION TAG
Phe 73-EXPRESSION TAG
Thr 74-EXPRESSION TAG
Ser 75-EXPRESSION TAG
Ser 76-EXPRESSION TAG
Gly 77-EXPRESSION TAG
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight37178.8
Non-Polymers*Number of molecules3
Total formula weight547.9
All*Total formula weight37726.7
*Water molecules are not included.

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PDB entries from 2024-03-27

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