3W8Q
Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 350 | 39237.1 | 1 | UniProt (Q02750) Pfam (PF00069) | Homo sapiens (human) | MAP kinase kinase 1, MAPKK 1, MKK1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1 |
| 2 | B (A) | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 1 | Chemie (AGS) | |||
| 3 | C (A) | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
A: 39 - 382 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Ala 292 | Thr 292 | engineered mutation |
| Ala 298 | Ser 298 | engineered mutation |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| His 386 | - | expression tag |
| His 387 | - | expression tag |
| His 388 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39237.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 523.2 | |
| All* | Total formula weight | 39760.4 |
