3W7R

Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dihydroorotate dehydrogenase (quinone), mitochondrial	polymer	390	42636.4	1	UniProt (Q02127) Pfam (PF01180)	Homo sapiens (human)	DHOdehase, Dihydroorotate oxidase
2	B (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
3	C, D, E, F, G... (A)	DECYLAMINE-N,N-DIMETHYL-N-OXIDE	non-polymer		201.3	6	Chemie (DDQ)
4	I (A)	2,6-dioxo-5-[2-(4-phenylphenyl)ethyl]-1,2,3,6- tetrahydropyrimidine-4-carboxylic acid	non-polymer		336.3	1	Chemie (W7A)
5	J (A)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	1	Chemie (FMN)
6	AA, BA, CA, DA, EA... (A)	GLYCEROL	non-polymer		92.1	22	Chemie (GOL)
7	GA (A)	OROTIC ACID	non-polymer		156.1	1	Chemie (ORO)
8	HA, IA, JA, KA (A)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
9	LA, MA, NA, OA, PA... (A)	ACETATE ION	non-polymer		59.0	7	Chemie (ACT)
10	SA (A)	water	water		18.0	317	Chemie (HOH)

Sequence modifications

A: 30 - 396 (UniProt: Q02127)

PDB	External Database	Details
Met 7	-	expression tag
Gly 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
Ser 19	-	expression tag
Ser 20	-	expression tag
Gly 21	-	expression tag
His 22	-	expression tag
Ile 23	-	expression tag
Asp 24	-	expression tag
Asp 25	-	expression tag
Asp 26	-	expression tag
Asp 27	-	expression tag
Lys 28	-	expression tag
His 29	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42636.4
Non-Polymers*	Number of molecules	43
	Total formula weight	5016.0
All*	Total formula weight	47652.4

*Water molecules are not included.