3W2O
EGFR Kinase domain T790M/L858R Mutant with TAK-285
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 331 | 38021.0 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | N-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide | non-polymer | 548.0 | 1 | Chemie (03P) | |||
| 3 | C (A) | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A: 698 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| His 692 | - | expression tag |
| His 693 | - | expression tag |
| His 694 | - | expression tag |
| His 695 | - | expression tag |
| His 696 | - | expression tag |
| His 697 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Arg 858 | Leu 858 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38021.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 548.0 | |
| All* | Total formula weight | 38568.9 |
