3W10
Aurora kinase A complexed to pyrazole aminoquinoline I
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Aurora kinase A | polymer | 278 | 32154.9 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A |
| 2 | A | 1-(3-methoxyphenyl)-N-(5-methyl-1H-pyrazol-3-yl)isoquinolin-3-amine | non-polymer | 330.4 | 1 | Chemie (RO9) | |||
| 3 | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A: 126 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Ala 287 | Thr 287 | ENGINEERED MUTATION |
| Ala 288 | Thr 288 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32154.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 330.4 | |
| All* | Total formula weight | 32485.2 |
