3W0U
human Glyoxalase I with an N-hydroxypyridone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Lactoylglutathione lyase | polymer | 187 | 21086.0 | 2 | UniProt (Q04760) Pfam (PF00903) | Homo sapiens (human) | Aldoketomutase, Glyoxalase I, Glx I, Ketone-aldehyde mutase, Methylglyoxalase, S-D-lactoylglutathione methylglyoxal lyase |
| 2 | C, D (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | E, F (A, B) | N-[3-(1-Hydroxy-6-oxo-4-phenyl-1,6-dihydro-pyridin-2-yl)-5-methanesulfonylamino-phenyl]-methanesulfonamide | non-polymer | 449.5 | 2 | Chemie (HPW) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A, B: 0 - 183 (UniProt: Q04760)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42172.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1029.8 | |
| All* | Total formula weight | 43201.8 |
