3VN4
Crystal structure of the exosite-containing fragment of human ADAMTS13 (P475S mutant)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | A disintegrin and metalloproteinase with thrombospondin motifs 13 | polymer | 410 | 45339.1 | 1 | UniProt (Q76LX8) Pfam (PF17771) Pfam (PF00090) Pfam (PF19236) Pfam (PF05986) | Homo sapiens (human) | ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease |
| 2 | B (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 3 | C (C) | beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose | branched | 326.3 | 1 | In PDB GlyTouCan (G36855WW) | |||
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E (A) | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) | |||
| 6 | F (A) | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A: 287 - 685 (UniProt: Q76LX8)
| PDB | External Database | Details |
|---|---|---|
| Gly 285 | - | expression tag |
| Arg 286 | - | expression tag |
| Ser 475 | Pro 475 | engineered mutation |
| Ser 686 | - | expression tag |
| Arg 687 | - | expression tag |
| Leu 688 | - | expression tag |
| Glu 689 | - | expression tag |
| Asn 690 | - | expression tag |
| Leu 691 | - | expression tag |
| Tyr 692 | - | expression tag |
| Phe 693 | - | expression tag |
| Gln 694 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45339.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 750.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 401.4 | |
| All* | Total formula weight | 46491.2 |
