3VKE

Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Poly(rC)-binding protein 1	polymer	76	8462.8	4	UniProt (Q15365) Pfam (PF00013)	Homo sapiens (human)	Alpha-CP1, Heterogeneous nuclear ribonucleoprotein E1, hnRNP E1, Nucleic acid-binding protein SUB2.3
2	E, F, G, H (R, S, T, U)	DNA (5'-D(P*AP*CP*CP*CP*CP*A)-3')	polymer	6	1738.2	4
3	I, J, K, L, M... (A, B, C, D, R...)	water	water		18.0	71	Chemie (HOH)

Sequence modifications

A, B, C, D: 14 - 86 (UniProt: Q15365)

PDB	External Database	Details
His 12	-	expression tag
Met 13	-	expression tag
Ser 54	Cys 54	engineered mutation
Trp 87	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	40803.9
All*	Total formula weight	40803.9

*Water molecules are not included.