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3VJL

Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor #2

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Dipeptidyl peptidase 4polymer74085880.02UniProt (P27487)
Pfam (PF00930)
Pfam (PF00326)
Homo sapiens (human)ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV soluble form
2C, D, E, F, G
(C, D, E, F, G)
2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.45In PDB
GlyTouCan (G42666HT)
3H, L
(A, B)
[(2S,4S)-4-{4-[1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]piperidin-1-yl}pyrrolidin-2-yl](1,3-thiazolidin-3-yl)methanonenon-polymer479.62Chemie (W94)
4I, J, K, M, N...
(A, B)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.26Chemie (NAG)
5P, Q
(A, B)
waterwater18.0894Chemie (HOH)
Sequence modifications
A, B: 33 - 766 (UniProt: P27487)
PDBExternal DatabaseDetails
His 767-expression tag
His 768-expression tag
His 769-expression tag
His 770-expression tag
His 771-expression tag
His 772-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight171760.1
BranchedNumber of molecules5
Total formula weight2122.0
Non-Polymers*Number of molecules8
Total formula weight2286.4
All*Total formula weight176168.4
*Water molecules are not included.

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PDB entries from 2025-07-09

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