3VJK
Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with MP-513
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dipeptidyl peptidase 4 | polymer | 740 | 85880.0 | 2 | UniProt (P27487) Pfam (PF00930) Pfam (PF00326) In PDB | Homo sapiens (human) | ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV soluble form |
2 | C, D, E, F, G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
3 | A, B | {(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-yl}(1,3-thiazolidin-3-yl)methanone | non-polymer | 426.6 | 2 | Chemie (M51) | |||
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
5 | water | water | 18.0 | 456 | Chemie (HOH) |
Sequence modifications
A, B: 33 - 766 (UniProt: P27487)
PDB | External Database | Details |
---|---|---|
His 767 | - | expression tag |
His 768 | - | expression tag |
His 769 | - | expression tag |
His 770 | - | expression tag |
His 771 | - | expression tag |
His 772 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 171760.1 | |
Branched | Number of molecules | 5 |
Total formula weight | 2122.0 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 2401.6 | |
All* | Total formula weight | 176283.7 |