3VJC
Crystal structure of the human squalene synthase in complex with zaragozic acid A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Squalene synthase | polymer | 343 | 39449.0 | 6 | UniProt (P37268) Pfam (PF00494) | Homo sapiens (human) | SQS, SS, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase |
| 2 | G, I, L, N, Q... (A, B, C, D, E...) | Zaragozic acid A | non-polymer | 690.7 | 6 | Chemie (ZGA) | |||
| 3 | H, J, M, O, R... (A, B, C, D, E...) | PHOSPHATE ION | non-polymer | 95.0 | 6 | Chemie (PO4) | |||
| 4 | K, P (B, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | U, V, W, X, Y... (A, B, C, D, E...) | water | water | 18.0 | 1390 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 31 - 370 (UniProt: P37268)
| PDB | External Database | Details |
|---|---|---|
| Gly 28 | - | expression tag |
| Ser 29 | - | expression tag |
| His 30 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 236693.8 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 4762.8 | |
| All* | Total formula weight | 241456.6 |
