3VJC
Crystal structure of the human squalene synthase in complex with zaragozic acid A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Squalene synthase | polymer | 343 | 39449.0 | 6 | UniProt (P37268) Pfam (PF00494) | Homo sapiens (human) | SQS, SS, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase |
| 2 | G, I, L, N, Q... (A, B, C, D, E...) | Zaragozic acid A | non-polymer | 690.7 | 6 | Chemie (ZGA) PubChem (44308545) PubChem (53315060) PubChem (21681278) PubChem (44287785) PubChem (44356045) PubChem (44318857) PubChem (53757375) PubChem (56950392) PubChem (68363353) PubChem (68333335) PubChem (124008) PubChem (101631777) PubChem (9831460) PubChem (9918010) PubChem (133612333) PubChem (11422574) PubChem (134555398) PubChem (134939723) PubChem (90701941) PubChem (15940206) PubChem (6438355) PubChem (9810194) PubChem (9874808) PubChem (9874809) PubChem (9896338) PubChem (9918011) PubChem (9939855) PubChem (155887994) PubChem (155931769) PubChem (162875223) | |||
| 3 | H, J, M, O, R... (A, B, C, D, E...) | PHOSPHATE ION | non-polymer | 95.0 | 6 | Chemie (PO4) PubChem (1061) | |||
| 4 | K, P (B, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | U, V, W, X, Y... (A, B, C, D, E...) | water | water | 18.0 | 1390 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 31 - 370 (UniProt: P37268)
| PDB | External Database | Details |
|---|---|---|
| Gly 28 | - | expression tag |
| Ser 29 | - | expression tag |
| His 30 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 236693.8 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 4762.8 | |
| All* | Total formula weight | 241456.6 |
