3VI5
Human hematopoietic prostaglandin D synthase inhibitor complex structures
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Hematopoietic prostaglandin D synthase | polymer | 198 | 23256.7 | 4 | UniProt (O60760) Pfam (PF02798) Pfam (PF14497) | Homo sapiens (human) | H-PGDS, GST class-sigma, Glutathione S-transferase, Glutathione-dependent PGD synthase, Glutathione-requiring prostaglandin D synthase, Prostaglandin-H2 D-isomerase |
| 2 | E, F (A, B) | GLUTATHIONE | non-polymer | 307.3 | 2 | Chemie (GSH) | |||
| 3 | G, J (C, D) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | H, K (C, D) | 1-amino-9,10-dioxo-4-[(4-sulfamoylphenyl)amino]-9,10-dihydroanthracene-2-sulfonic acid | non-polymer | 473.5 | 2 | Chemie (M4M) | |||
| 5 | I (D) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 699 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 199 (UniProt: O60760)
| PDB | External Database | Details |
|---|---|---|
| Met 144 | Asn 144 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 93026.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1733.9 | |
| All* | Total formula weight | 94760.8 |
