3VHU

Mineralocorticoid receptor ligand-binding domain with spironolactone

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mineralocorticoid receptor	polymer	294	34006.2	1	UniProt (P08235) Pfam (PF00104) In PDB	Homo sapiens (human)	MR, Nuclear receptor subfamily 3 group C member 2
2	A	SPIRONOLACTONE	non-polymer		416.6	1	Chemie (SNL)
3		water	water		18.0	62	Chemie (HOH)

Sequence modifications

A: 712 - 984 (UniProt: P08235)

PDB	External Database	Details
Met 691	-	expression tag
Gly 692	-	expression tag
Ser 693	-	expression tag
Asp 694	-	expression tag
Lys 695	-	expression tag
Ile 696	-	expression tag
Ile 697	-	expression tag
His 698	-	expression tag
His 699	-	expression tag
His 700	-	expression tag
His 701	-	expression tag
His 702	-	expression tag
His 703	-	expression tag
Glu 704	-	expression tag
Asn 705	-	expression tag
Leu 706	-	expression tag
Tyr 707	-	expression tag
Phe 708	-	expression tag
Gln 709	-	expression tag
Gly 710	-	expression tag
Ser 711	-	expression tag
Ser 808	Cys 808	engineered mutation
Leu 810	Ser 810	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34006.2
Non-Polymers*	Number of molecules	1
	Total formula weight	416.6
All*	Total formula weight	34422.8

*Water molecules are not included.