3VHU
Mineralocorticoid receptor ligand-binding domain with spironolactone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mineralocorticoid receptor | polymer | 294 | 34006.2 | 1 | UniProt (P08235) Pfam (PF00104) | Homo sapiens (human) | MR, Nuclear receptor subfamily 3 group C member 2 |
| 2 | B (A) | SPIRONOLACTONE | non-polymer | 416.6 | 1 | Chemie (SNL) PubChem (16757735) PubChem (18594034) PubChem (5267) PubChem (16394537) PubChem (24867532) PubChem (24884066) PubChem (44268286) PubChem (44280002) PubChem (1742267) PubChem (1742266) PubChem (50937095) PubChem (941624) PubChem (53316433) PubChem (54670637) PubChem (58649021) PubChem (59078570) PubChem (59106600) PubChem (53485777) PubChem (60108251) PubChem (60113353) PubChem (59105084) PubChem (6093165) PubChem (73896881) PubChem (6419955) PubChem (6432512) PubChem (76974557) PubChem (5833) PubChem (6604008) PubChem (6604182) PubChem (89555390) PubChem (6710654) PubChem (7061088) PubChem (7061090) PubChem (90660429) PubChem (10477021) PubChem (1255733) PubChem (11509929) PubChem (1425524) PubChem (11863525) PubChem (11869418) PubChem (11869419) PubChem (11869420) PubChem (11869578) PubChem (11869580) PubChem (11957686) PubChem (12358364) PubChem (100923457) PubChem (117072388) PubChem (7058140) PubChem (124303478) PubChem (124304402) PubChem (124900200) PubChem (129010254) PubChem (11869579) PubChem (122680945) PubChem (124304445) PubChem (124746581) PubChem (124900199) PubChem (129009897) PubChem (138756141) PubChem (131698401) PubChem (139421976) PubChem (154731467) | |||
| 3 | C (A) | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A: 712 - 984 (UniProt: P08235)
| PDB | External Database | Details |
|---|---|---|
| Met 691 | - | expression tag |
| Gly 692 | - | expression tag |
| Ser 693 | - | expression tag |
| Asp 694 | - | expression tag |
| Lys 695 | - | expression tag |
| Ile 696 | - | expression tag |
| Ile 697 | - | expression tag |
| His 698 | - | expression tag |
| His 699 | - | expression tag |
| His 700 | - | expression tag |
| His 701 | - | expression tag |
| His 702 | - | expression tag |
| His 703 | - | expression tag |
| Glu 704 | - | expression tag |
| Asn 705 | - | expression tag |
| Leu 706 | - | expression tag |
| Tyr 707 | - | expression tag |
| Phe 708 | - | expression tag |
| Gln 709 | - | expression tag |
| Gly 710 | - | expression tag |
| Ser 711 | - | expression tag |
| Ser 808 | Cys 808 | engineered mutation |
| Leu 810 | Ser 810 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34006.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 416.6 | |
| All* | Total formula weight | 34422.8 |
