3VD8

Crystal structure of human AIM2 PYD domain with MBP fusion

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Maltose-binding periplasmic protein, Interferon-inducible protein AIM2	polymer	489	53973.4	1	UniProt (P0AEY0) UniProt (O14862) Pfam (PF01547) Pfam (PF02758)	Escherichia coli (human)	MBP, MMBP, Maltodextrin-binding protein, Absent in melanoma 2
2	B (B)	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		666.6	1	In PDB BIRD (PRD_900010) GlyTouCan (G87171PZ)		alpha-maltotetraose
3	C, D, E, F (A)	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
4	G, H, I, J (A)	POTASSIUM ION	non-polymer		39.1	4	Chemie (K)
5	K (A)	water	water		18.0	325	Chemie (HOH)

Sequence modifications

A: 1 - 358 (UniProt: P0AEY0)

PDB	External Database	Details
Met 0	-	expression tag
Ala 82	Asp 108	engineered mutation
Ala 83	Lys 109	engineered mutation
Ala 172	Glu 198	engineered mutation
Ala 173	Asn 199	engineered mutation
Ala 239	Lys 265	engineered mutation
Ala 359	-	linker
Ala 360	-	linker
Leu 361	-	linker
Ala 362	-	linker
Ala 363	-	linker
Ala 364	-	linker
Gln 365	-	linker
Thr 366	-	linker
Asn 367	-	linker
Ala 368	-	linker
Val 369	-	linker
Asp 370	-	linker

A: 1001 - 1107 (UniProt: O14862)

PDB	External Database	Details
Ala 1108	-	expression tag
Ala 1109	-	expression tag
Ala 1110	-	expression tag
Leu 1111	-	expression tag
Glu 1112	-	expression tag
His 1113	-	expression tag
His 1114	-	expression tag
His 1115	-	expression tag
His 1116	-	expression tag
His 1117	-	expression tag
His 1118	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	53973.4
Branched	Number of molecules	1
	Total formula weight	666.6
Non-Polymers*	Number of molecules	8
	Total formula weight	404.7
All*	Total formula weight	55044.7

*Water molecules are not included.