3VA4

Crystal structure of the mammalian MDC1 FHA domain complexed with CHK2 pThr68 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	Mediator of DNA damage checkpoint protein 1	polymer	132	14589.7	2	UniProt (Q5PSV9) Pfam (PF00498)	Mus musculus
2	B (C)	Serine/threonine-protein kinase Chk2	polymer	11	1349.3	1	UniProt (O96017)	Homo sapiens	CHK2 checkpoint homolog, Cds1 homolog, Hucds1, hCds1, Checkpoint kinase 2
3	D, E, F (A, C, B)	water	water		18.0	153	Chemie (HOH)

Sequence modifications

A, B: 29 - 139 (UniProt: Q5PSV9)

PDB	External Database	Details
Met 8	-	expression tag
Gly 9	-	expression tag
Ser 10	-	expression tag
Ser 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
Ser 18	-	expression tag
Ser 19	-	expression tag
Gly 20	-	expression tag
Leu 21	-	expression tag
Val 22	-	expression tag
Pro 23	-	expression tag
Arg 24	-	expression tag
Gly 25	-	expression tag
Ser 26	-	expression tag
His 27	-	expression tag
Met 28	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	30528.8
All*	Total formula weight	30528.8

*Water molecules are not included.