3V8X

The crystal structure of transferrin binding protein A (TbpA) from Neisserial meningitidis serogroup B in complex with full length human transferrin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Transferrin-binding protein 1	polymer	904	101213.3	1	UniProt (Q9K0U9) Pfam (PF07715) Pfam (PF00593) In PDB	Neisseria meningitidis serogroup B
2	B	Serotransferrin	polymer	698	77153.9	1	UniProt (P02787) Pfam (PF00405) In PDB	Homo sapiens (human)	Transferrin, Beta-1 metal-binding globulin, Siderophilin
3	C	N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1932.7	1	In PDB GlyTouCan (G98736SM)
4	D	N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1770.6	1	In PDB GlyTouCan (G74608QW)
5	A	(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE	non-polymer		306.4	2	Chemie (C8E)
6		water	water		18.0	204	Chemie (HOH)

Sequence modifications

A: 25 - 915 (UniProt: Q9K0U9)

PDB	External Database	Details
Met 12	-	expression tag
Asp 13	-	expression tag
Ile 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
His 23	-	expression tag
His 24	-	expression tag
Val 435	Ile 435	variant
Tyr 913	Met 913	engineered mutation

B: -18 - 679 (UniProt: P02787)

PDB	External Database	Details
Val 429	Ile 448	variant

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	178367.2
Branched	Number of molecules	2
	Total formula weight	3703.3
Non-Polymers*	Number of molecules	2
	Total formula weight	612.9
All*	Total formula weight	182683.5

*Water molecules are not included.