3V5Q
Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | NT-3 growth factor receptor | polymer | 297 | 33940.5 | 2 | UniProt (Q16288) Pfam (PF07714) In PDB | Homo sapiens (human) | GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase |
| 2 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | A, B | 1-(3-{[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-6-yl]amino}phenyl)-3-[3-(trifluoromethyl)phenyl]urea | non-polymer | 503.5 | 2 | Chemie (0F4) | |||
| 4 | water | water | 18.0 | 189 | Chemie (HOH) |
Sequence modifications
A, B: 530 - 832 (UniProt: Q16288)
| PDB | External Database | Details |
|---|---|---|
| Gly -8 | - | cloning artifact |
| Ala -7 | - | cloning artifact |
| Met -6 | - | cloning artifact |
| His -5 | - | cloning artifact |
| Ser -4 | - | cloning artifact |
| Gly -3 | - | cloning artifact |
| Ile -2 | - | cloning artifact |
| His -1 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67881.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1042.4 | |
| All* | Total formula weight | 68923.4 |
