3V4K
First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | DNA dC->dU-editing enzyme APOBEC-3G | polymer | 203 | 23634.7 | 2 | UniProt (Q9HC16) Pfam (PF05240) In PDB | Homo sapiens (human) | APOBEC-related cytidine deaminase, APOBEC-related protein, ARCD, APOBEC-related protein 9, ARP-9, CEM-15, CEM15 |
2 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
5 | water | water | 18.0 | 493 | Chemie (HOH) |
Sequence modifications
A, B: 191 - 380 (UniProt: Q9HC16)
PDB | External Database | Details |
---|---|---|
Gly 178 | - | expression tag |
Pro 179 | - | expression tag |
Leu 180 | - | expression tag |
Gly 181 | - | expression tag |
Ser 182 | - | expression tag |
Pro 183 | - | expression tag |
Glu 184 | - | expression tag |
Phe 185 | - | expression tag |
Glu 186 | - | expression tag |
Leu 187 | - | expression tag |
Gly 188 | - | expression tag |
Thr 189 | - | expression tag |
Thr 190 | - | expression tag |
Lys 234 | Leu 234 | engineered mutation |
Ala 243 | Cys 243 | engineered mutation |
Lys 310 | Phe 310 | engineered mutation |
Ala 356 | Cys 356 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 47269.4 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 381.2 | |
All* | Total formula weight | 47650.5 |