3UVM
Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | WD repeat-containing protein 5 | polymer | 318 | 34794.4 | 1 | UniProt (P61964) Pfam (PF00400) | Homo sapiens (human) | WDR5, BMP2-induced 3-kb gene protein |
| 2 | B (B) | Histone-lysine N-methyltransferase MLL4 | polymer | 10 | 1107.3 | 1 | UniProt (Q9UMN6) | Homo sapiens | Lysine N-methyltransferase 2D, KMT2D, Myeloid/lymphoid or mixed-lineage leukemia protein 4, Trithorax homolog 2, WW domain-binding protein 7, WBP-7 |
| 3 | C, D (A, B) | water | water | 18.0 | 170 | Chemie (HOH) |
Sequence modifications
A: 21 - 334 (UniProt: P61964)
| PDB | External Database | Details |
|---|---|---|
| Gly 17 | - | expression tag |
| Ala 18 | - | expression tag |
| Met 19 | - | expression tag |
| Gly 20 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35901.7 | |
| All* | Total formula weight | 35901.7 |
