3UVL
Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | WD repeat-containing protein 5 | polymer | 318 | 34794.4 | 1 | UniProt (P61964) Pfam (PF00400) | Homo sapiens (human) | WDR5, BMP2-induced 3-kb gene protein |
| 2 | B (B) | Histone-lysine N-methyltransferase MLL3 | polymer | 11 | 1106.3 | 1 | UniProt (Q8NEZ4) | Homo sapiens | Homologous to ALR protein, Lysine N-methyltransferase 2C, KMT2C, Myeloid/lymphoid or mixed-lineage leukemia protein 3 |
| 3 | C, D (A, B) | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
A: 21 - 334 (UniProt: P61964)
B: 3762 - 3772 (UniProt: Q8NEZ4)
| PDB | External Database | Details |
|---|---|---|
| Gly 17 | - | expression tag |
| Ala 18 | - | expression tag |
| Met 19 | - | expression tag |
| Gly 20 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 3763 | Cys 4708 | engineered mutation |
| Ala 3766 | Ser 4711 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35900.7 | |
| All* | Total formula weight | 35900.7 |
