3UVK
Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | WD repeat-containing protein 5 | polymer | 318 | 34794.4 | 1 | UniProt (P61964) Pfam (PF00400) | Homo sapiens (human) | WDR5, BMP2-induced 3-kb gene protein |
| 2 | B (B) | Histone-lysine N-methyltransferase MLL2 | polymer | 11 | 1176.4 | 1 | UniProt (O14686) | Homo sapiens | ALL1-related protein, Lysine N-methyltransferase 2B, KMT2B, Myeloid/lymphoid or mixed-lineage leukemia protein 2 |
| 3 | C (A) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 1 | Chemie (BTB) | |||
| 4 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 206 | Chemie (HOH) |
Sequence modifications
A: 21 - 334 (UniProt: P61964)
| PDB | External Database | Details |
|---|---|---|
| Gly 17 | - | expression tag |
| Ala 18 | - | expression tag |
| Met 19 | - | expression tag |
| Gly 20 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35970.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 305.3 | |
| All* | Total formula weight | 36276.1 |
