3UUZ
Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Cationic trypsin | polymer | 223 | 23424.4 | 2 | UniProt (P00760) Pfam (PF00089) In PDB | Bos taurus (bovine) | Beta-trypsin, Alpha-trypsin chain 1, Alpha-trypsin chain 2 |
| 2 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 3 | A, B | {[(7-carbamimidoylnaphthalen-2-yl)methyl][4-({1-[(1E)-ethanimidoyl]piperidin-4-yl}oxy)phenyl]sulfamoyl}acetic acid | non-polymer | 537.6 | 2 | Chemie (0CB) | |||
| 4 | A, B | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 593 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 245 (UniProt: P00760)
| PDB | External Database | Details |
|---|---|---|
| Glu 97 | Asn 102 | engineered mutation |
| Tyr 99 | Leu 104 | engineered mutation |
| Ser 172 | Tyr 175 | engineered mutation |
| Ser 173 | Pro 176 | engineered mutation |
| Phe 174 | Gly 177 | engineered mutation |
| Ile 175 | Gln 178 | engineered mutation |
| Ala 190 | Ser 195 | engineered mutation |
| Phe 227 | Val 228 | engineered mutation |
| Leu 231 | Val 232 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46848.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1431.7 | |
| All* | Total formula weight | 48280.5 |
