3UUA
Crystal structure of hERa-LBD (Y537S) in complex with bisphenol-AF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Estrogen receptor | polymer | 251 | 28640.7 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
| 2 | B (B) | Estrogen receptor | polymer | 251 | 28656.7 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
| 3 | C, D (F, G) | Nuclear receptor coactivator 1 | polymer | 13 | 1591.9 | 2 | UniProt (Q15788) | Homo sapiens | NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1 |
| 4 | E, F (A, B) | 4,4'-(1,1,1,3,3,3-hexafluoropropane-2,2-diyl)diphenol | non-polymer | 336.2 | 2 | Chemie (0CZ) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A: 302 - 552 (UniProt: P03372)
B: 302 - 552 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 537 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60481.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 672.5 | |
| All* | Total formula weight | 61153.7 |
