3UP2
Aurora A in complex with RPM1686
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Aurora kinase A | polymer | 279 | 32359.1 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A |
| 2 | A | 4-[(4-{[2-(trifluoromethoxy)phenyl]amino}pyrimidin-2-yl)amino]benzoic acid | non-polymer | 390.3 | 1 | Chemie (0C8) | |||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
A: 123 - 401 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Asp 287 | Thr 287 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32359.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 514.5 | |
| All* | Total formula weight | 32873.6 |
