3UO7

Crystal structure of Human Thymine DNA Glycosylase Bound to Substrate 5-carboxylcytosine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (C)	5'-D(*CP*AP*GP*CP*TP*CP*TP*GP*TP*AP*CP*AP*TP*GP*AP*GP*CP*AP*GP*TP*GP*GP*A)-3'	polymer	23	7105.6	1
2	B (D)	5'-D(*CP*CP*AP*CP*TP*GP*CP*TP*CP*AP*(1CC)P*GP*TP*AP*CP*AP*GP*AP*GP*CP*TP*GP*T)-3'	polymer	23	7045.5	1
3	C, D (A, B)	G/T mismatch-specific thymine DNA glycosylase	polymer	201	22728.3	2	UniProt (Q13569) Pfam (PF03167)	Homo sapiens (human)	Thymine-DNA glycosylase, TDG

Sequence modifications

A, B: 111 - 308 (UniProt: Q13569)

PDB	External Database	Details
Ser 108	-	expression tag
Asn 109	-	expression tag
Ala 110	-	expression tag
Ala 140	Asn 140	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	59607.7
All*	Total formula weight	59607.7

*Water molecules are not included.