3UIJ
Crystal structure of human Survivin K62Y/H80W mutant in complex with Smac/DIABLO(1-15) peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Baculoviral IAP repeat-containing protein 5 | polymer | 143 | 16553.8 | 2 | UniProt (O15392) Pfam (PF00653) | Homo sapiens (human) | Apoptosis inhibitor 4, Apoptosis inhibitor survivin |
| 2 | C, D (P, Q) | Diablo homolog, mitochondrial | polymer | 15 | 1552.7 | 2 | UniProt (Q9NR28) | Homo sapiens | Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase, Smac |
| 3 | E, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 15 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 142 (UniProt: O15392)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Tyr 62 | Lys 62 | engineered mutation |
| Trp 80 | His 80 | engineered mutation |
| Lys 129 | Glu 129 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 36213.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 36344.0 |
