3UFF
Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cdelta
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein kinase C delta type | polymer | 65 | 7314.5 | 2 | UniProt (P28867) Pfam (PF00130) | Mus musculus (mouse) | nPKC-delta |
| 2 | C, D, H, I (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | E, F, G, J, K... (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 6 | Chemie (PO4) | |||
| 4 | M, N (A, B) | water | water | 18.0 | 239 | Chemie (HOH) |
Sequence modifications
A, B: 231 - 280 (UniProt: P28867)
| PDB | External Database | Details |
|---|---|---|
| Gly 222 | - | expression tag |
| Ser 223 | - | expression tag |
| Arg 224 | - | expression tag |
| Arg 225 | - | expression tag |
| Ala 226 | - | expression tag |
| Ser 227 | - | expression tag |
| Val 228 | - | expression tag |
| Gly 229 | - | expression tag |
| Ser 230 | - | expression tag |
| Thr 236 | Tyr 236 | engineered mutation |
| Glu 281 | - | expression tag |
| Phe 282 | - | expression tag |
| Ile 283 | - | expression tag |
| Val 284 | - | expression tag |
| Thr 285 | - | expression tag |
| Asp 286 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 14629.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 831.5 | |
| All* | Total formula weight | 15460.4 |
