3UE4
Structural and spectroscopic analysis of the kinase inhibitor bosutinib binding to the Abl tyrosine kinase domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase ABL1 | polymer | 287 | 33223.0 | 2 | UniProt (P00519) Pfam (PF07714) | Homo sapiens (human) | Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150 |
| 2 | C, D (A, B) | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | non-polymer | 530.4 | 2 | Chemie (DB8) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 152 | Chemie (HOH) |
Sequence modifications
A, B: 229 - 512 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Gly 226 | - | expression tag |
| His 227 | - | expression tag |
| Met 228 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66446.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1060.9 | |
| All* | Total formula weight | 67506.9 |
