3UDQ
Crystal Structure of BACE with Compound 13
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Beta-secretase 1 | polymer | 404 | 45156.7 | 1 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (human) | BACE, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2 |
| 2 | A | (4S)-6-bromo-1,1-dioxido-3,4-dihydro-2H-thiochromen-4-yl (3S,5'R)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate | non-polymer | 491.4 | 1 | Chemie (09E) | |||
| 3 | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A: -3 - 392 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Arg 393 | - | EXPRESSION TAG |
| Ser 394 | - | EXPRESSION TAG |
| His 395 | - | EXPRESSION TAG |
| His 396 | - | EXPRESSION TAG |
| His 397 | - | EXPRESSION TAG |
| His 398 | - | EXPRESSION TAG |
| His 399 | - | EXPRESSION TAG |
| His 400 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45156.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 491.4 | |
| All* | Total formula weight | 45648.1 |
