3UA7

Crystal Structure of the Human Fyn SH3 domain in complex with a peptide from the Hepatitis C virus NS5A-protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Tyrosine-protein kinase Fyn	polymer	64	7171.8	4	UniProt (P06241) Pfam (PF00018) In PDB	Homo sapiens (human)	Proto-oncogene Syn, Proto-oncogene c-Fyn, Src-like kinase, SLK, p59-Fyn
2	E, F	Non-structural protein 5A	polymer	12	1314.6	2	UniProt (Q9YKI6) UniProt (by SIFTS) (P26663) In PDB	Hepatitis C virus	NS5A
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6	C, D	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7	C, D	FORMIC ACID	non-polymer		46.0	2	Chemie (FMT)
8		water	water		18.0	173	Chemie (HOH)

Sequence modifications

A, B, C, D: 81 - 143 (UniProt: P06241)

PDB	External Database	Details
Met 80	-	initiating methionine

E, F: 1 - 11 (UniProt: Q9YKI6)

PDB	External Database	Details
Ace 0	-	acetylation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	31316.3
Non-Polymers*	Number of molecules	7
	Total formula weight	373.4
All*	Total formula weight	31689.7

*Water molecules are not included.