3UA3

Crystal Structure of Protein Arginine Methyltransferase PRMT5 in complex with SAH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Protein arginine N-methyltransferase 5	polymer	745	85545.0	2	UniProt (P46580) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286)	Caenorhabditis elegans
2	C, D (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
3	E, F (A, B)	water	water		18.0	146	Chemie (HOH)

Sequence modifications

A, B: 1 - 734 (UniProt: P46580)

PDB	External Database	Details
Mse -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag
Leu 735	-	expression tag
Glu 736	-	expression tag
His 737	-	expression tag
His 738	-	expression tag
His 739	-	expression tag
His 740	-	expression tag
His 741	-	expression tag
His 742	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	171089.9
Non-Polymers*	Number of molecules	2
	Total formula weight	768.8
All*	Total formula weight	171858.7

*Water molecules are not included.