3U8W
Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Triazolopyridazinone inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Mitogen-activated protein kinase 14 | polymer | 366 | 41998.9 | 1 | UniProt (Q16539) Pfam (PF00069) In PDB | Homo sapiens (human) | MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, SAPK2A |
2 | A | 3-[3-(2-chloro-6-fluorophenyl)-5-ethyl-6-oxo-5,6-dihydro[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-N-cyclopropyl-4-methylbenzamide | non-polymer | 465.9 | 1 | Chemie (09J) | |||
3 | water | water | 18.0 | 65 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: Q16539)
PDB | External Database | Details |
---|---|---|
Gly -5 | - | expression tag |
Ser -4 | - | expression tag |
His -3 | - | expression tag |
Met -2 | - | expression tag |
Leu -1 | - | expression tag |
Glu 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 41998.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 465.9 | |
All* | Total formula weight | 42464.8 |