3U73
Crystal structure of stabilized human uPAR mutant in complex with ATF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (U) | Urokinase plasminogen activator surface receptor | polymer | 283 | 31455.4 | 1 | UniProt (Q03405) Pfam (PF00021) | Homo sapiens (human) | U-PAR, uPAR, Monocyte activation antigen Mo3 |
| 2 | B (A) | Urokinase-type plasminogen activator | polymer | 132 | 15000.0 | 1 | UniProt (P00749) Pfam (PF00051) | Homo sapiens (human) | U-plasminogen activator, uPA, Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A, Urokinase-type plasminogen activator chain B |
| 3 | C (B) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 4 | D, E (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) |
Sequence modifications
U: 1 - 283 (UniProt: Q03405)
| PDB | External Database | Details |
|---|---|---|
| Cys 47 | His 69 | engineered mutation |
| Cys 259 | Asn 281 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46455.3 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1435.3 | |
| All* | Total formula weight | 47890.7 |
