3U6H
Crystal structure of c-Met in complex with pyrazolone inhibitor 26
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 309 | 35215.7 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met |
| 2 | B (A) | N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide | non-polymer | 528.5 | 1 | Chemie (03X) | |||
| 3 | C (A) | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
A: 1048 - 1351 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| His 1352 | - | expression tag |
| His 1353 | - | expression tag |
| His 1354 | - | expression tag |
| His 1355 | - | expression tag |
| His 1356 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35215.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 528.5 | |
| All* | Total formula weight | 35744.2 |
