3U2Z
Activator-Bound Structure of Human Pyruvate Kinase M2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pyruvate kinase isozymes M1/M2 | polymer | 533 | 58161.0 | 4 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (human) | Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58 |
| 2 | E, M, S, Y (A, B, C, D) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 4 | Chemie (FBP) | |||
| 3 | AA, BA, CA, DA, EA... (D, A, B, C) | UNKNOWN ATOM OR ION | non-polymer | 21 | Chemie (UNX) | ||||
| 4 | L, T (B, C) | 6-(3-aminobenzyl)-4-methyl-2-methylsulfinyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one | non-polymer | 372.5 | 2 | Chemie (07T) | |||
| 5 | FA, GA, HA, IA (A, B, C, D) | water | water | 18.0 | 367 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 531 (UniProt: P14618)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 232643.9 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 2105.4 | |
| All* | Total formula weight | 234749.3 |
