3U2Z

Activator-Bound Structure of Human Pyruvate Kinase M2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Pyruvate kinase isozymes M1/M2	polymer	533	58161.0	4	UniProt (P14618) Pfam (PF00224) Pfam (PF02887)	Homo sapiens (human)	Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58
2	E, M, S, Y (A, B, C, D)	1,6-di-O-phosphono-beta-D-fructofuranose	non-polymer		340.1	4	Chemie (FBP) PubChem (718) PubChem (10267) PubChem (172313) PubChem (440117) PubChem (5702629) PubChem (12800340) PubChem (16219368) PubChem (24802138) PubChem (46937007) PubChem (445557) PubChem (92209487) PubChem (124383956) PubChem (124540446) PubChem (135053794) PubChem (89534552) PubChem (92209485) PubChem (92209486) PubChem (123134048) PubChem (124202619) PubChem (124427861) PubChem (124524513) PubChem (124604817) PubChem (130233858) PubChem (133126640) PubChem (135055131) PubChem (140434362) PubChem (146159004) PubChem (160510795)
3	AA, BA, CA, DA, EA... (D, A, B, C)	UNKNOWN ATOM OR ION	non-polymer			21	Chemie (UNX)
4	L, T (B, C)	6-(3-aminobenzyl)-4-methyl-2-methylsulfinyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one	non-polymer		372.5	2	Chemie (07T) PubChem (44246499) PubChem (60156291) PubChem (93233258)
5	FA, GA, HA, IA (A, B, C, D)	water	water		18.0	367	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 531 (UniProt: P14618)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	232643.9
Non-Polymers*	Number of molecules	27
	Total formula weight	2105.4
All*	Total formula weight	234749.3

*Water molecules are not included.