3U2C
Aldose reductase in complex with NSAID-type inhibitor at 1.0 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aldose reductase | polymer | 316 | 35898.3 | 1 | UniProt (P15121) Pfam (PF00248) | Homo sapiens (human) | AR, Aldehyde reductase, Aldo-keto reductase family 1 member B1 |
| 2 | B (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (71717786) PubChem (165382010) | |||
| 3 | C, H (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) PubChem (8117) | |||
| 4 | D, E (A) | 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE | non-polymer | 178.2 | 2 | Chemie (PG5) PubChem (8189) | |||
| 5 | F (A) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) PubChem (311) | |||
| 6 | G (A) | [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid | non-polymer | 356.4 | 1 | Chemie (SUZ) PubChem (5352) PubChem (1548885) PubChem (1548887) PubChem (11245227) PubChem (11861119) PubChem (11865478) PubChem (16046677) PubChem (66624622) PubChem (131707333) | |||
| 7 | I (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) PubChem (8200) | |||
| 8 | J (A) | water | water | 18.0 | 309 | Chemie (HOH) |
Sequence modifications
A: 0 - 315 (UniProt: P15121)
| PDB | External Database | Details |
|---|---|---|
| Ile 4 | Leu 5 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35898.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2054.9 | |
| All* | Total formula weight | 37953.2 |
