3TZV
Crystal structure of an iNKT TCR in complex with CD1d-lysophosphatidylcholine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, G) | Invariant Natural Killer T Cell Receptor chain A | polymer | 213 | 23598.1 | 2 | Homo sapiens (human) | ||
| 2 | B, F (B, H) | Invariant Natural Killer T Cell Receptor chain B | polymer | 259 | 29183.5 | 2 | Homo sapiens (human) | ||
| 3 | C (C) | Antigen-presenting glycoprotein CD1d | polymer | 276 | 31393.5 | 1 | UniProt (P15813) Pfam (PF16497) Pfam (PF07654) | Homo sapiens (human) | R3G1 |
| 4 | D (D) | Beta-2-microglobulin | polymer | 99 | 11748.2 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | Beta-2-microglobulin form pI 5.3 |
| 5 | G (E) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 6 | H (C) | (4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide | non-polymer | 522.7 | 1 | Chemie (LSC) | |||
| 7 | I (C) | HEXANE | non-polymer | 86.2 | 1 | Chemie (HEX) | |||
| 8 | J (C) | DODECANE | non-polymer | 170.3 | 1 | Chemie (D12) | |||
| 9 | K (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 10 | L, M (C, G) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
C: 3 - 278 (UniProt: P15813)
| PDB | External Database | Details |
|---|---|---|
| Pro 2 | - | expression tag |
| Gln 42 | Asn 60 | engineered mutation |
| Gln 108 | Asn 126 | engineered mutation |
| Gln 163 | Asn 181 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 148704.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 367.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 871.3 | |
| All* | Total formula weight | 149943.4 |
