3TV3

Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with Man9

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	L	PGT128 light chain, Ig lambda-2 chain C regions	polymer	211	22223.6	1	UniProt (P0CG05) In PDB	Homo sapiens (human)
2	H	PGT128 heavy chain, Ig gamma-1 chain C region	polymer	239	25562.7	1	UniProt (P01857) Pfam (PF07654) In PDB	Homo sapiens (human)
3	A	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose	branched		1315.1	1	In PDB GlyTouCan (G65997KL)
4	L, H	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
5	H	AMYLAMINE	non-polymer		87.2	1	Chemie (AML)
6	H	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	1	Chemie (EPE)
7		water	water		18.0	306	Chemie (HOH)

Sequence modifications

L: 1 - 106 (PDB: 3TV3)
L: 107 - 215 (UniProt: P0CG05)
H: 1 - 113 (PDB: 3TV3)
H: 114 - 231 (UniProt: P01857)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47786.3
Branched	Number of molecules	1
	Total formula weight	1315.1
Non-Polymers*	Number of molecules	6
	Total formula weight	693.8
All*	Total formula weight	49795.3

*Water molecules are not included.