3TUD

Crystal structure of SYK kinase domain with N-(4-methyl-3-(8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(trifluoromethyl)benzamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein kinase SYK	polymer	299	34881.0	1	UniProt (P43405) Pfam (PF07714) In PDB	Homo sapiens (human)	Spleen tyrosine kinase
2	A	N-{4-methyl-3-[8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]phenyl}-3-(trifluoromethyl)benzamide	non-polymer		529.5	1	Chemie (FPX)
3		water	water		18.0	51	Chemie (HOH)

Sequence modifications

A: 343 - 635 (UniProt: P43405)

PDB	External Database	Details
His 636	-	expression tag
His 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34881.0
Non-Polymers*	Number of molecules	1
	Total formula weight	529.5
All*	Total formula weight	35410.5

*Water molecules are not included.