3TUC
Crystal structure of SYK kinase domain with 1-benzyl-N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase SYK | polymer | 299 | 34881.0 | 1 | UniProt (P43405) Pfam (PF07714) In PDB | Homo sapiens (human) | Spleen tyrosine kinase |
| 2 | A | 1-benzyl-N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamide | non-polymer | 508.5 | 1 | Chemie (FPW) | |||
| 3 | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence modifications
A: 343 - 635 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| His 636 | - | expression tag |
| His 637 | - | expression tag |
| His 638 | - | expression tag |
| His 639 | - | expression tag |
| His 640 | - | expression tag |
| His 641 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34881.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 508.5 | |
| All* | Total formula weight | 35389.5 |
