3TT3
Crystal Structure of LeuT in the inward-open conformation in complex with Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Leucine transporter LeuT | polymer | 519 | 57909.3 | 1 | UniProt (O67854) Pfam (PF00209) | Aquifex aeolicus | |
| 2 | B (L) | mouse monoclonal 1gG1 Fab fragment, heavy chain | polymer | 218 | 24208.6 | 1 | Mus musculus | ||
| 3 | C (H) | mouse monoclonal 1gG1 Fab fragment, kappa light chain | polymer | 221 | 23985.9 | 1 | Mus musculus | ||
| 4 | D (A) | octyl 1-thio-beta-D-glucopyranoside | non-polymer | 308.4 | 1 | Chemie (SOG) PubChem (20765008) PubChem (22840433) PubChem (3035440) PubChem (24802438) PubChem (24802439) PubChem (363418) PubChem (44120068) PubChem (446404) PubChem (46782626) PubChem (656909) PubChem (53720324) PubChem (53720325) PubChem (53720326) PubChem (53720327) PubChem (89711063) PubChem (92151891) PubChem (95858717) PubChem (95858718) PubChem (96327603) PubChem (96367497) PubChem (96367498) PubChem (98118655) PubChem (97944776) PubChem (101682121) PubChem (102041106) PubChem (124524845) PubChem (171395924) |
Sequence modifications
A: 1 - 513 (UniProt: O67854)
| PDB | External Database | Details |
|---|---|---|
| Ala 268 | Tyr 268 | engineered mutation |
| Ala 288 | Lys 288 | engineered mutation |
| Val 354 | Thr 354 | engineered mutation |
| Ala 355 | Ser 355 | engineered mutation |
| Gly 514 | - | expression tag |
| Thr 515 | - | expression tag |
| Leu 516 | - | expression tag |
| Val 517 | - | expression tag |
| Pro 518 | - | expression tag |
| Arg 519 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 106103.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 308.4 | |
| All* | Total formula weight | 106412.2 |
