3TQ9

Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with methotrexate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dihydrofolate reductase	polymer	178	20924.2	1	UniProt (Q83AB2) Pfam (PF00186)	Coxiella burnetii
2	B (A)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	1	Chemie (NDP)
3	C (A)	METHOTREXATE	non-polymer		454.4	1	Chemie (MTX)

Sequence modifications

A: 1 - 161 (UniProt: Q83AB2)

PDB	External Database	Details
Glu 162	-	expression tag
Asn 163	-	expression tag
Leu 164	-	expression tag
Tyr 165	-	expression tag
Phe 166	-	expression tag
Gln 167	-	expression tag
Gly 168	-	expression tag
His 169	-	expression tag
His 170	-	expression tag
His 171	-	expression tag
His 172	-	expression tag
His 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag
His 178	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	20924.2
Non-Polymers*	Number of molecules	2
	Total formula weight	1199.9
All*	Total formula weight	22124.0

*Water molecules are not included.