3TOG
HIV-1 Protease - Epoxydic Inhibitor Complex (pH 9 - Monoclinic Crystal form P21)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D (A, B, C, D) | Gag-Pol polyprotein | polymer | 99 | 10740.7 | 4 | UniProt (P03367) Pfam (PF00077) | Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1) | Pr160Gag-Pol, Matrix protein p17, MA, Capsid protein p24, CA, Spacer peptide p2, Nucleocapsid protein p7, NC, Transframe peptide, TF, p6-pol, p6*, Protease, PR, Retropepsin, Reverse transcriptase/ribonuclease H, Exoribonuclease H, p66 RT, p51 RT, p15, Integrase, IN |
2 | E, G, H (A, B, D) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
3 | F, I (A, D) | (S)-N-((2S,3S,4R,5R)-4-amino-3,5-dihydroxy-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-phenoxyacetamido)butanamide | non-polymer | 533.7 | 2 | BIRD (PRD_001019) Chemie (079) | |||
4 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 269 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 99 (UniProt: P03367)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 507 | engineered mutation |
Ile 33 | Leu 533 | engineered mutation |
Ile 63 | Leu 563 | engineered mutation |
Ala 67 | Cys 567 | engineered mutation |
Ala 95 | Cys 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 42962.7 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1301.7 | |
All* | Total formula weight | 44264.4 |